Models of Graded Closed Craniocerebral Injury in Rats
نویسندگان
چکیده
#1student, #2professor & The first clinical medical college Wenzhou Medical University, Wenzhou, China Abstract: To build closed traumatic brain injury models in varying degrees with high accuracy, repeatability as well as easy operation, We use lateral fluid percussion method to simulate the rats’ three types of closed traumatic brain injury models in slight, moderate and serious degrees after 24 hours and valuate the situations of neurological deficit of the rats in each group through NSS, then conduct quantitative measurement of brain water content as well as blood brain barrier at the same time, finding that the more serious the rat’s traumatic brain injury degree is, the higher NSS scores shows, and the more serious damage brain water content as well as blood brain barrier possess, the differences of which have statistical significance (P<0.05).So we have built a traumatic brain injury model in varying degrees with high stability and easy operation, which lays the foundation for the preliminary study of traumatic brain injury to a certain extent.
منابع مشابه
Relationship of mechanical impact magnitude to neurologic dysfunction severity in a rat traumatic brain injury model
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